@media screen and (min-width: 400px) {
  .b-changes-btnbox__text {
    font-size: 14px;
  }
}
@media screen and (min-width: 576px) {
  .b-container {
    padding: 0 30px;
  }
  .b-header-background1 {
    width: 428px;
    height: 428px;
    left: calc(50% - 214px);
    top: -6px;
  }
  .b-header-background1 .b-img-1 {
    width: 292px;
    top: 68px;
    left: 68px;
  }
  .b-header-background1 .b-img-2 {
    width: 186px;
    top: 121px;
    left: 121px;
  }
  .b-header-middle {
    margin-top: 201px;
  }
  .b-header-img {
    max-width: 450px;
  }
  .b-doctor-img {
    max-width: 550px;
    margin-left: calc(50% - 286px);
  }
  .b-buy-boximg {
    width: 426px;
    height: 426px;
    margin-left: calc(50% - 213px);
  }
  .b-buy-boximg .b-img-1 {
    width: 426px;
  }
  .b-buy-boximg .b-img-2 {
    width: 170px;
    top: 53px;
    left: 133px;
  }
  .b-buy-boximg .b-img-3 {
    width: 426px;
    top: 120px;
  }
  .b-changes-btnbox__text {
    font-size: 16px;
  }
}

@media screen and (min-width: 768px) {
  .b-header-background1 {
    width: 513px;
    height: 513px;
    left: -125px;
    top: -26px;
  }
  .b-header-background1 .b-img-1 {
    width: 349px;
    top: 82px;
    left: 82px;
  }
  .b-header-background1 .b-img-2 {
    width: 222px;
    top: 146px;
    left: 146px;
  }
  .b-header-background2 {
    display: block;
    width: 180px;
    height: 180px;
    top: 21px;
    right: -27px;
  }
  .b-header-background2 .b-img-1 {
    width: 280px;
    top: -44px;
    right: 37px;
  }
  .b-header-background2 .b-img-2 {
    width: 276px;
    top: -25px;
    right: -63px;
  }
  .b-header-sliders {
    width: 752px;
    height: 280px;
    margin-left: calc(50% - 376px);
  }
  .b-header-sliders__img {
    width: 280px;
    height: 280px;
    margin-right: 51px;
  }
  .b-header-sliders__text {
    width: 304px;
    margin-top: 50px;
    font-size: 24px;
  }
  .b-header-sliders .b-btnbox {
    bottom: 56px;
    left: 336px;
  }
  .b-header-sliders .b-btnbox .b-btn {
    width: 40px;
    margin-right: 12px;
  }
  .b-effect {
    padding: 120px 0 104px;
  }
  .b-effect-item {
    display: inline-block;
    vertical-align: top;
    width: calc(50% - 36px);
    margin-right: 32px;
  }
  .b-effect-item:first-of-type {
    margin-right: 32px;
  }
  .b-effect-item .b-p:nth-of-type(1) {
    margin-bottom: 0;
    height: 48px;
    display: table-cell;
    vertical-align: middle;
  }
  .b-effect-head {
    display: table;
    margin-bottom: 16px;
    width: 100%;
    text-align: center;
  }
  .b-effect-background1 {
    top: -143px;
  }
  .b-effect-background2 {
    bottom: -145px;
  }
  .b-doctor {
    overflow: visible;
    padding-bottom: 60px;
  }
  .b-doctor .b-h2 {
    text-align: left;
  }
  .b-doctor-textbox {
    max-width: 50%;
    margin-left: 50%;
  }
  .b-doctor-img {
    position: absolute;
    max-width: 100%;
    width: 550px;
    right: 50%;
    bottom: -76px;
    margin: 0;
  }
}

@media screen and (min-width: 992px) {
  .b-h1 {
    font-size: 64px;
  }
  .b-h2 {
    font-size: 32px;
  }
  .b-nav {
    display: inline-block;
  }
  .b-online {
    display: inline-block;
  }
  .b-header {
    padding-bottom: 192px;
  }
  .b-header-p {
    font-size: 24px;
    margin-top: 24px;
  }
  .b-header-button {
    margin: 56px 0 0;
  }
  .b-header-background1 {
    width: 686px;
    height: 686px;
    left: -180px;
    top: -79px;
  }
  .b-header-background1 .b-img-1 {
    width: 466px;
    top: 110px;
    left: 110px;
  }
  .b-header-background1 .b-img-2 {
    width: 296px;
    top: 195px;
    left: 195px;
  }
  .b-header-background2 {
    display: block;
    width: 240px;
    height: 240px;
    top: 0;
    right: -0;
  }
  .b-header-background2 .b-img-1 {
    width: 374px;
    top: -59px;
    right: 21px;
  }
  .b-header-background2 .b-img-2 {
    width: 368px;
    top: -34px;
    right: -111px;
  }
  .b-header-top {
    text-align: initial;
  }
  .b-header-img {
    display: inline-block;
    vertical-align: top;
    margin-right: 31px; /**/
  }
  .b-header-middle {
    margin-top: 260px;
  }
  .b-header-middle__content {
    display: inline-block;
    vertical-align: top;
    width: calc(100% - 500px);
    max-width: 640px;
    text-align: left;
  }
  .b-header-bottom {
    margin-top: 120px;
  }
  .b-changes {
    padding-bottom: 120px;
  }
  .b-changes-left {
    text-align: left;
    width: 50%;
    display: inline-block;
    vertical-align: top;
  }
  .b-changes-left .b-h2 {
    max-width: 500px;
  }
  .b-changes-right {
    width: calc(49% - 90px);
    max-width: 576px;
    display: inline-block;
    vertical-align: top;
    margin-left: 90px;
  }
  .b-changes-right__img {
    max-width: 100%;
    margin-top: 0;
  }
  .b-changes-right .b-slider {
    position: relative;
  }
  .b-changes-right .b-slider-img1 {
    position: absolute;
    width: 21%;
    top: 9%;
    left: 15.5%;
  }
  .b-changes-right .b-slider-img2 {
    position: absolute;
    width: 41.5%;
    top: 9%;
    right: 0;
  }
  .b-changes-right .b-slider-img3 {
    position: absolute;
    width: 52.5%;
    bottom: 11.5%;
    left: 0;
  }
  .b-changes-right .b-slider-img4 {
    position: absolute;
    width: 30.5%;
    bottom: 11.5%;
    right: 0;
  }
  .b-changes-btnbox {
    max-width: 640px;
  }
  .b-changes-btnbox__range {
    margin-top: 24px;
    max-width: 640px;
  }
  .b-changes-btnbox__range::-ms-thumb {
    width: 150px;
  }
  .b-changes-btnbox__text {
    display: inline-block;
    vertical-align: middle;
    width: 24.3%;
    padding: 0 5px;
    text-align: center;
  }
  .b-changes-btnbox .b-view {
    display: inline-block;
    color: #303778;
    font-weight: bold;
  }
  .b-effect {
    padding: 120px 0 104px;
  }
  .b-effect-item {
    display: inline-block;
    vertical-align: top;
    width: calc(33% - 36px);
  }
  .b-effect-item:last-of-type {
    margin-right: 0;
  }
  .b-effect-img {
    width: 192px;
    margin-bottom: 24px;
    margin-top: 64px;
  }
  .b-effect-background1 {
    position: absolute;
    width: 80px;
    height: 80px;
    top: -175px;
    left: 3%;
  }
  .b-effect-background1 .b-img-1 {
    width: 80px;
    position: relative;
    z-index: 10;
  }
  .b-effect-background1 .b-img-2 {
    position: absolute;
    z-index: 5;
    width: 66px;
    left: 57px;
    bottom: 32px;
  }
  .b-effect-background2 {
    position: absolute;
    width: 80px;
    height: 80px;
    bottom: -143px;
    right: 3%;
  }
  .b-effect-background2 .b-img-1 {
    width: 80px;
    position: relative;
    z-index: 10;
  }
  .b-effect-background2 .b-img-2 {
    position: absolute;
    z-index: 5;
    width: 65px;
    right: 69px;
    bottom: 32px;
  }
  .b-composition {
    padding: 120px 0 40px;
  }
  .b-composition-item {
    clear: both;
    margin: 80px 0;
    height: 416px;
  }
  .b-composition-item .b-p {
    max-width: 515px;
    margin-left: 500px;
  }
  .b-composition .b-item-2 img {
    float: right;
  }
  .b-composition .b-item-2 .b-p {
    margin-left: 0;
    margin-right: 560px;
  }
  .b-composition-img {
    margin: 0 auto;
    float: left;
  }
  .b-composition-background1 {
    width: 768px;
    height: 768px;
    bottom: -436px;
    right: -546px;
  }
  .b-composition-background1 .b-img-1 {
    width: 315px;
    top: 227px;
    left: 227px;
  }
  .b-composition-background1 .b-img-2 {
    width: 468px;
    left: -33px;
    top: 116px;
  }
  .b-composition-background2 {
    width: 582px;
    height: 582px;
    top: 40px;
    left: -134px;
  }
  .b-composition-background2 .b-img-1 {
    width: 582px;
  }
  .b-composition-background3 {
    width: 582px;
    height: 582px;
    bottom: -331px;
    left: -80px;
  }
  .b-composition-background3 .b-img-1 {
    width: 582px;
  }
  .b-reviews {
    padding-bottom: 80px;
  }
  .b-reviews .b-h2 {
    margin-bottom: 80px;
  }
  .b-reviews-boxitem {
    display: flex;
    justify-content: space-between;
  }
  .b-reviews-item {
    margin-bottom: 0;
    max-width: 31.6%;
    margin: 0;
  }
  .b-reviews-item:last-of-type {
    margin-right: 0;
  }
  .b-reviews-item__textbox {
    padding: 20px;
  }
  .b-reviews-background1 {
    width: 582px;
    height: 582px;
    top: 327px;
    left: -200px;
  }
  .b-reviews-background1 .b-img-1 {
    width: 582px;
  }
  .b-reviews-background2 {
    width: 582px;
    height: 582px;
    bottom: 318px;
    right: -195px;
  }
  .b-reviews-background2 .b-img-1 {
    width: 582px;
  }
  .b-buy {
    padding: 84px 0 80px;
  }
  .b-buy .b-h2 {
    margin-bottom: 80px;
  }
  .b-buy-boximg {
    display: inline-block;
    vertical-align: top;
    margin-left: 0;
    margin-right: calc(49% - 426px);
  }
  .b-buy-boxform {
    display: inline-block;
    vertical-align: top;
    margin-right: calc(50% - 385px);
  }
}

@media screen and (min-width: 1200px) {
  .b-composition .b-container {
    padding: 0 90px;
  }
  .b-doctor-textbox {
    max-width: 57%;
    margin-left: 43%;
  }
  .b-doctor-img {
    width: 630px;
    right: 55%;
  }
  .b-reviews {
    padding: 120px 0;
  }
  .b-reviews-item__textbox {
    padding: 32px;
  }
  .b-buy {
    padding: 120px 0;
  }
  .b-buy-boximg {
    width: 528px;
    height: 528px;
    margin-right: calc(49% - 528px);
  }
  .b-buy-boximg .b-img-1 {
    width: 528px;
  }
  .b-buy-boximg .b-img-2 {
    width: 145px;
    top: 65px;
    left: 285px; /*385*/
  }
  .b-buy-boximg .b-img-3 {
    width: 528px;
    top: 158px;
  }
  .b-buy-form {
    padding: 63px;
  }
  .b-buy-boxform {
    margin-right: calc(50% - 480px);
    max-width: 480px;
  }
  .b-buy-boxform__bg1 {
    width: 80px;
    bottom: -40px;
    left: -40px;
  }
  .b-buy-boxform__bg2 {
    width: 59px;
    top: -48px;
    right: 32px;
  }
  .b-buy-boxform__bg3 {
    width: 77px;
    top: -59px;
    right: -41px;
  }
}

@media screen and (min-width: 1372px) {
  .b-nav {
    margin-right: 7.5%;
  }
  .b-container {
    padding: 0;
  }
  .b-header-background1 {
    width: 856px;
    height: 856px;
    left: -81px;
    top: -96px;
  }
  .b-header-background1 .b-img-1 {
    width: 582px;
    top: 137px;
    left: 137px;
  }
  .b-header-background1 .b-img-2 {
    width: 370px;
    top: 243px;
    left: 243px;
  }
  .b-header-background2 {
    width: 300px;
    height: 300px;
    top: 0;
    right: 0;
  }
  .b-header-background2 .b-img-1 {
    width: 468px;
    top: -90px;
    right: 13px;
  }
  .b-header-background2 .b-img-2 {
    width: 460px;
    top: -59px;
    right: -153px;
  }
  .b-header-img {
    max-width: 100%;
    width: 528px;
  }
  .b-header-middle {
    margin-top: 320px;
  }
  .b-header-sliders {
    margin-left: 620px;
  }
  .b-composition .b-container {
    padding: 0 125px;
  }
  .b-composition-item .b-p {
    margin-left: 560px;
  }
  .b-composition-item:nth-of-type(2) .b-p {
    margin-left: 0;
    margin-right: 560px;
  }
  .b-doctor {
    padding: 120px 0 104px;
  }
  .b-doctor-img {
    width: 689px;
    right: 55%;
    bottom: -120px;
  }
}